BIOWIN project started

We recently started our new JTF project “AI-assisted resource-efficient production of the antifibrinolytic ε-aminocaproic acid and bio-nylon” together with our partners from Helmholtz-UFZ and MPI Neurorecogniation. The goal of the project is to use and streamline microbial biocatalysts for the AI-based development of an efficient ε-aminocaproic acid production process. Cyclohexane and renewable fatty acid derivatives will serve as primary substrates. Envisioned reaction setups include biofilm reactors and microbial consortia to distribute tasks among different strains. AI will be fed by reaction parameters of the in vivo cascade reaction to determine and optimize feasible and sustainable process setups. For eco-efficient production of nylon precursors, the pathways will be adapted and transferred into cyanobacteria providing energy and reduction equivalents via photosynthesis.

PhD Position in Bioprocess Engineering

We currently offer a PhD position in the field of bioprocess engineering with emphasis on biofilm reactors for chemical production. Experience in bioprocess engineering, biotechnology, microbiology, biochemistry or equivalent in a relevant subject area are needed. For details see: Link.

New Paper on Entropic Repulsion by Cholesterol Multilayers

Based on a cooperation with colleagues from Dresden, we newly published a paper in Nature on a new mechanism counteracting bioadhesion by entropic repulsion of orientational fluctuations in cholesterol multilayers. Our results not only reveal this new mechanism of entropic repulsion to be relevant in the surface properties of Collembola, but, also shows the high specificity to the cholesterol chemistry. For further reading see here.

New Paper on Combining Electrochemistry and Biotransformation for Synthesis of Nylon Precursors from Wood Feedstock

We newly published a paper in Green Chemistry on enabling a new biotechnological process combining electrochemical hydrogenation and microbial biotransformation of lignin feedstock. Our results show this process to be synthesis adipic acid as a Nylon building block at high yield, which shows option for the production of polyamides by natural growing resources. For further reading see here.

New Paper on an Instructive Phenotype Switch of Breast Cancer Cells during Migration across Matrix Interfaces

We newly published a paper in ACS Materials & Interfaces on a distinct phenotype switch of breast cancer cells during transmigration across sharp interfaces of biomimetic extracellular matrices. Our findings suggest that the switch of the breast cancer cell line MDA-MB-231 into a more aggressive phenotype correlates with a strong nuclear deformation and DNA damage occurring during the transmigration from a dense into an open matrix. For further reading see here.

New Paper on Hydrogen Production in Photobiofilm Reactors

Rohan Karande together with collaborators newly published a paper in Bioresource Technology on continuous hydrogen production by cyanobacteria in capillary photobiofilm reactors. Therein they show that hydrogen production by different cyanobacterial strains is stably possible over weeks at a defined parameter range of the bioreactor. For further reading see here.