Battaglia S, De Santis S, Rutigliano M, Sallustio F, Picerno A, Frassanito MA, Schäfer I, Vacca A, Moschetta A, Seibel P, Battaglia M, Villani G.
Uridine and pyruvate protect T cells’ proliferative capacity from mitochondrial toxic antibiotics: a clinical pilot study
Sci Rep. 2021 Jun 18;11(1):12841. doi: 10.1038/s41598-021-91559-8.
[PUBMED] [Full Text] [PDF]

Piccinin E, Sardanelli AM, Seibel P, Moschetta A, Cocco T, Villani G.
PGC-1s in the Spotlight with Parkinson’s Disease.
Int J Mol Sci. 2021 Mar 28;22(7):3487. doi: 10.3390/ijms22073487.
[PUBMED] [Full Text] [PDF]


Hsu MJ, Karkossa I, Schäfer I, Christ M, Kühne H, Schubert K, Rolle-Kampczyk UE, Kalkhof S, Nickel S, Seibel P, von Bergen M, Christ B.
Mitochondrial Transfer by Human Mesenchymal Stromal Cells Ameliorates Hepatocyte Lipid Load in a Mouse Model of NASH.
Biomedicines. 2020 Sep 14;8(9):350. doi: 10.3390/biomedicines8090350.
[PUBMED] [Full Text] [PDF]


Siegismund CS, Schäfer I, Seibel P, Kühl U, Schultheiss HP, Lassner D.
Mitochondrial Haplogroups and Expression Studies of commonly used Human Cell Lines.
Mitochondrion. 2016 Sep;30:236-47. doi: 10.1016/j.mito.2016.08.012. Epub 2016 Aug 22.
[PUBMED] [Full Text]

Halwachs S, Schäfer I, Kneuer C, Seibel P, Honscha W.
Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model.
Toxicol Appl Pharmacol. 2016 Aug 15;305:66-74. doi: 10.1016/j.taap.2016.06.007. Epub 2016 Jun 8.
[PUBMED] [Full Text]

Bluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R
N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.
Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. eCollection 2016.
[PUBMED] [Full Text] [PDF]


Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
J Cell Biol. 2015 Dec 7;211(5):1057-75. doi: 10.1083/jcb.201404147
[PUBMED] [Abstract]

Schubert S, Heller S, Löffler B, Schäfer I, Seibel M, Villani G, Seibel P
Generation of Rho Zero Cells: Visualization and Quantification of the mtDNA Depletion Process.
Int. J. Mol. Sci. 2015, 16, 9850-9865. doi: 10.3390/ijms16059850
[PUBMED] [Abstract] [Full Text] [PDF]

Pacak CA, Preble JM, Kondo H, Seibel P, Levitsky S, Del Nido PJ, Cowan DB, McCully JD.
Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function.
Biol Open. 2015 Apr 10. pii: BIO201511478. doi: 10.1242/bio.201511478 [Epub ahead of print].
[PUBMED] [Full Text] [PDF]


Müller-Höcker J, Schäfer S, Krebs S, Blum H, Zsurka G, Kunz WS, Prokisch H, Seibel P, Jung A
Oxyphil Cell Metaplasia in the Parathyroids Is Characterized by Somatic Mitochondrial DNA Mutations in NADH Dehydrogenase Genes and Cytochrome c Oxidase Activity-Impairing Genes.
Am J Pathol. 2014;184(11):2922-35. doi: 10.1016/j.ajpath.2014.07.015
[PUBMED] [Full Text]

Gößringer M, Helmecke D, Köhler K, Schön A, Kirsebom LA, Bindereif A, Hartmann RK
Enzymatic RNA synthesis using Bacteriophage T7 RNA polymerase.
In: Methods in RNA Biochemistry. 2014. Hartmann RK, Bindereif A, Schön A, Westhof E (eds). Wiley-VCH: pp. 3-28.

Gimple O, Schön A
Direct determination of RNA sequence and modification by radiolabeling methods.
In: Methods in RNA Biochemistry. 2014. Hartmann RK, Bindereif A, Schön A, Westhof E (eds). Wiley-VCH: pp. 175-204


Heller S, Schubert S, Krehan M, Schäfer I, Seibel M, Latorre D, Villani G, Seibel P
Efficient repopulation of genetically derived rho zero cells with exogenous mitochondria.
PLoS One. 2013 Sep 3;8(9):e73207. doi: 10.1371/journal.pone.0073207
[PUBMED] [Full Text] [PDF]

Wassermann L, Halwachs S, Baumann D, Schäfer I, Seibel P, Honscha W
Assessment of ABCG2-mediated transport of xenobiotics across the blood-milk barrier of dairy animals using a new MDCKII in vitro model.
Arch Toxicol. 2013 May 8. [Epub ahead of print]
[PUBMED] [Abstract] [Full Text] [PDF]


Hansen A, Schäfer I, Knappe D, Seibel P, Hoffmann R
Intracellular toxicity of proline-rich antimicrobial peptides shuttled into mammalian cells by the cell-penetrating peptide penetratin.
Antimicrob Agents Chemother. 2012 Oct;56(10):5194-201. Epub 2012 Jul 30
[PUBMED] [Abstract] [Full Text] [PDF]

Krehan M, Heubeck C, Menzel N, Seibel P, Schön A
RNase MRP RNA and RNase P activity in plants are accociated with a Pop1p containing complex.
Nucleic Acids Res. 2012 May 27. [Epub ahead of print]
[PUBMED] [Abstract] [Full Text] [PDF]


Halwachs S, Schäfer I, Seibel P, Honscha W
Antiepileptic Drugs Reduce the Efficacy of Methotrexate Chemotherapy through Accelerated Degradation of the Reduced Folate Carrier by the Ubiquitin-Proteasome Pathway.
Chemotherapy. 2011 Sep 6;57(4):345-356. Epub 2011 Sep 6. doi:10.1159/000330461
[PUBMED] [Abstract] [Full Text] [PDF]

Heidler J, Al-Furoukh N, Kukat C, Salwig I, Ingelmann ME, Seibel P, Krüger M, Holtz J, Wittig I, Braun T, Szibor M
Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes.
J Biol Chem. 2011 Sep 16;286(37):32086-93. Epub 2011 Jul 19. doi:10.1074/jbc.M111.221986
[PUBMED] [Abstract] [Full Text] [PDF]

Halwachs S, Lakoma C, Schäfer I, Seibel P, Honscha W
The antiepileptic drugs Phenobarbital and Carbamazepine reduce transport of methotrexate in rat choroid plexus by downregulation of the Reduced folate carrier.
Mol Pharmacol. 2011 Oct;80(4):621-9. Epub 2011 Jul 7. doi:10.1124/mol.111.072421
[PUBMED] [Abstract] [Full Text] [PDF]

D’Errico I, Salvatore L, Murzilli M, Lo Sasso G, Latorre D, Martelli N, Egorova AV, Polishuck R, Madeyski-Bengtson K, Lelliott C, Vidal-Puig AJ, Seibel P, Villani G, Moschetta A
Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a metabolic regulator of intestinal epithelial cell fate.
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6603-8. Epub 2011 Apr 5. doi:10.1073/pnas.1016354108
[PUBMED] [Abstract] [Full Text] [PDF]

Claus C, Chey S, Heinrich S, Reins M, Richardt N, Pinkert S, Fechner H, Gaunitz F, Schäfer I, Seibel P, Liebert UG
Involvement of p32 and microtubules in alteration of mitochondrial functions by rubella virus.
J Virol. 2011 Apr;85(8):3881-92. Epub 2011 Jan 19. doi:10.1128/JVI.02492-10
[PUBMED] [Abstract] [Full Text] [PDF]

Pacelli C, De Rasmo D, Signorile A, Grattagliano I, di Tullio G, D’Orazio A, Nico B, Comi GP, Ronchi D, Ferranini E, Pirolo D, Seibel P, Schubert S, Gaballo A, Villani G, Cocco T
Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson’s disease.
Biochim Biophys Acta. 2011 Aug;1812(8):1041-53. Epub 2011 Jan 5. doi:10.1016/j.bbadis.2010.12.022
[PUBMED] [Full Text]


Pacelli C, Latorre D, Cocco T, Capuano F, Kukat C, Seibel P, Villani G
Tight control of mitochondrial membrane potential by cytochrome c oxidase.
Mitochondrion. 2011 Mar;11(2):334-41. Epub 2010 Dec 13. doi:10.1016/j.mito.2010.12.004
[PUBMED] [Full Text]

Gralle M, Schäfer I, Seibel P, Pääbo S
A Functional Test of Neandertal and Modern Human Mitochondrial Targeting Sequences.
Biochem Biophys Res Commun. 2010 Nov 26;402(4):747-9. Epub 2010 Oct 25. doi:10.1016/j.bbrc.2010.10.099
[PUBMED] [Full Text]

Halwachs S, Lakoma C, Gebhardt R, Schäfer I, Seibel P, Honscha W
Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway.
Toxicol Appl Pharmacol. 2010 Jul;246(1-2):100-6. Epub 2010 May 6. doi:10.1016/j.taap.2010.04.020
[PUBMED] [Full Text]


Nass N, Kukat A, Seibel P, Brömme HJ, Schinzel R, Silber RE, Simm A
Advanced glycation end product accumulation in ρ0 cells without a functional respiratory chain.
Biol Chem. 2009 Sep;390(9):915-9.
[PUBMED] [Abstract] [PDF]

Halwachs S, Schäfer I, Seibel P, Honscha W
Antiepileptic drugs reduce efficacy of methotrexate chemotherapy by downregulation of Reduced folate carrier transport activity.
Leukemia. 2009 Jun;23(6):1087-97.
[PUBMED] [Abstract] [Full Text] [PDF]

Müller-Höcker J, Horvath R, Schäfer S, Hessel H, Müller-Felber W, Kühr J, Copeland WC, Seibel P
Mitochondrial DNA depletion and fatal infantile hepatic failure due to mutations in the mitochondrial polymerase gamma (POLG) gene A combined morphological/enzyme histochemical and immunocytochemical/biochemical and molecular genetic study.
J Cell Mol Med. 2011 Feb;15(2):445-56. Epub 2009 Jun 16. doi:10.1111/j.1582-4934.2009.00819.x
[PUBMED] [Abstract] [Full Text] [PDF]

Meisner A, Saffert A, Schreier P, Schön A
Fatty Acid α-Dioxygenase from Pisum sativum: Temporal and Spatial Regulation of Fatty Acid Metabolism during Germination and Plant Development.
J Plant Physiol. 2009 Mar 1;166(4):333-43. Epub 2008 Aug 28.
[PUBMED] [Full Text]


Seibel P, Di Nunno C, Kukat C, Schäfer I, Del Bo R, Bordoni A, Comi GP, Schön A, Capuano F, Latorre D, Villani G
Cosegregation of novel mitochondrial 16S rRNA gene mutations with the age-associated T414G variant in human cybrids
Nucleic Acids Res. 2008 Oct;36(18):5872-8.
[PUBMED] [Abstract] [Full Text] [PDF]

Kukat A, Kukat C, Brocher J, Schäfer I, Krohne G; Trounce IA, Villani G, Seibel P
Generation of ρ0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses.

Nucleic Acids Res. 2008 Apr;36(7):e44.
[PUBMED] [Abstract] [Full Text] [PDF]


Li D, Willkomm DK, Schön A, Hartmann, RK
RNase P of the Cyanophora paradoxa cyanelle: A plastid ribozyme.
Biochimie. 2007 Dec;89(12):1528-38.
[PUBMED] [Abstract]


Gimple O, Schön A
Direct determination of RNA sequence and modification by radiolabeling methods.
In: Methods in RNA Biochemistry. 2005. Hartmann RK, Bindereif A, Schön A and Westhof E (eds). Wiley-VCH:131-150.

Gruegelsiepe H, Schön A, Kirsebom LA, Hartmann RK
Enzymatic RNA Synthesis using Bacteriophage T7 RNA Polymerase.
In: Methods in RNA Biochemistry. 2005. Hartmann RK, Bindereif A, Schön A and Westhof E (eds). Wiley-VCH:1-21.


Flierl A, Jackson C, Cottrell B, Murdock D, Seibel P, Wallace DC
Targeted delivery of DNA to the mitochondrial compartment via import sequence-conjugated peptide nucleic acid.
Mol Ther. 2003 Apr;7(4):550-7.

Scheller K, Seibel P, Sekeris CE
Glucocorticoid and thyroid hormone receptors in mitochondria of animal cells.
Int Rev Cytol. 2003;222:1-61.


Vielhaber S, Varlamov DA, Kudina TA, Schröder R, Kappes-Horn K, Elger CE, Seibel M, Seibel P, Kunz WS
Expression pattern of mitochondrial respiratory chain enzymes in skeletal muscle of patients harboring the A3243G point mutation or large-scale deletions of mitochondrial DNA.
J Neuropathol Exp Neurol. 2002 Oct;61(10):885-95.

Schön A, Fingerhut C, Hess WR
Conserved and variable domains within divergent RNase P RNA gene sequences of Prochlorococcus strains.
Int J Syst Evol Microbiol. 2002 Jul;52(Pt 4):1383-9.
[PUBMED] [Abstract] [PDF]


Gimple O, Schön A
In vitro and in vivo processing of cyanelle tmRNA by RNase P.
Biol Chem. 2001 Oct;382(10):1421-9.
[PUBMED] [Abstract] [PDF]

Wagner M, Fingerhut C, Gross HJ, Schön A
The first phytoplasma RNase P RNA provides new insight into the sequence requirement of this ribozyme.
Nucleic Acids Res. 2001 Jun 15;29(12):2661-5.
[PUBMED] [Abstract] [Full Text] [PDF]

Kornblum C, Broicher R, Walther E, Seibel P, Reichmann H, Klockgether T, Herberhold C, Schröder R
Cricopharyngeal achalasia is a common cause of dysphagia in patients with mtDNA deletions.
Neurology. 2001 May 22;56(10):1409-12.
[PUBMED] [Abstract] [Full Text] [PDF]

Gedrange T, Luck O, Hesske G, Büttner C, Seibel P, Harzer W
Differential expression of myosin heavy-chain mRNA in muscles of mastication during functional advancement of the mandible in pigs.
Arch Oral Biol. 2001 Mar;46(3):215-20.

Wittig I, Augstein P, Brown GK, Fujii T, Rötig A, Rustin P, Munnich A, Seibel P, Thorburn D, Wissinger B, Tamboom K, Metspalu A, Lamantea E, Zeviani M, Wehnert MS
Sequence variations in the NDUFA1 gene encoding a subunit of complex I of the respiratory chain.
J Inherit Metab Dis. 2001 Feb;24(1):15-27.
[PUBMED] [Abstract] [PDF]

Heubeck C, Schön A
Cyanelle RNase P: Isolation and studies on function and structure of an organellar ribonucleoprotein enzyme.
Methods Enzymol. 2001;342:118-34.


Saffert A, Hartmann-Schreier J, Schön A, Schreier P
A dual function α-dioxigenase-peroxidase and NAD+ oxidoreductase active enzyme from germinating pea (Pisum sativum L.) rationalizing α-oxidation of fatty acids in plants.
Plant Physiol. 2000 Aug;123(4):1545-52.
[PUBMED] [Abstract] [Full Text] [PDF]

Göhlmann HW, Weiner J 3rd, Schön A, Herrmann R
Identification of a small RNA within the pdh gene cluster of Mycoplasma pneumoniae and Mycoplasma genitalium.
J Bacteriol. 2000 Jun;182(11):3281-4.
[PUBMED] [Abstract] [Full Text] [PDF]

Schröder R, Vielhaber S, Wiedemann FR, Kornblum C, Papassotiropoulos A, Broich P, Zierz S, Elger CE, Reichmann H, Seibel P, Klockgether T, Kunz WS
New insights into the metabolic consequences of large-scale mtDNA deletions: a quantitative analysis of biochemical, morphological, and genetic findings in human skeletal muscle.
J Neuropathol Exp Neurol. 2000 May;59(5):353-60.

Schön A
RNase P from cyanobacteria and chloroplasts: A key to the understanding of ribozyme evolution?
In: Ribozymes: Biochemistry and Biotechnology. 2000. Krupp G and Gaur RK (eds). Eaton Publishing, Natick, MA:133-148.


Seibel M, Bachmann C, Schmiedel J, Wilken N, Wilde F, Reichmann H, Isaya G, Seibel P, Pfeiler D
Processing of artificial peptide-DNA-conjugates by the mitochondrial intermediate peptidase (MIP).
Biol Chem. 1999 Jul-Aug;380(7-8):961-7.
[PUBMED] [Abstract] [PDF]

Schön A
Ribonuclease P: The diversity of a ubiquitous RNA processing enzyme.
FEMS Microbiol Rev. 1999 Jun;23(3):391-406.

Cordier A, Schön A
Cyanelle RNase P: RNA structure analysis and holoenzyme properties of an organellar ribonucleoprotein enzyme.
J Mol Biol. 1999 May 28;289(1):9-20.

Hess WR, Schön A
Characterization of rnpB, the gene encoding the RNA component of RNase P of Prochlorococcus marinus.
In: Marine cyanobacteria. Bulletin de l’Institut Océanographique. 1999. Monaco. Charpy L and Larkum AWD (eds):77-82.


Müller-Höcker J, Schäfer S, Copeland WC, Wiesner R, Seibel P
Immunohistochemical detection of human mtDNA polymerase gamma and of human mitochondrial transcription factor A in cytochrome-c-oxidase-deficient oxyphil cells of hyperfunctional parathyroids.
Virchows Arch. 1998 Dec;433(6):529-36.
[PUBMED] [Abstract] [PDF]

Hess WR, Fingerhut C, Schön A
RNase P RNA from Prochlorococcus marinus: The contribution of substrate domains to recognition by a cyanobacterial ribozyme.

FEBS Lett. 1998 Jul 17;431(2):138-42.

Fingerhut C, Schön A
Sequence and functional characterization of RNase P RNA from the chl a/b containing cyanobacterium Prochlorothrix hollandica.
FEBS Lett. 1998 May 29;428(3):161-4.

Müller-Höcker J, Jacob U, Seibel P
The common 4977 base pair deletion of mitochondrial DNA preferentially accumulates in the cardiac conduction system of patients with Kearns-Sayre syndrome.
Mod Pathol. 1998 Mar;11(3):295-301.

Müller-Höcker J, Jacob U, Seibel P
Hashimoto thyroiditis is associated with defects of cytochrome-c oxidase in oxyphil Askanazy cells and with the common deletion (4,977) of mitochondrial DNA.
Ultrastruct Pathol. 1998 Jan-Feb;22(1):91-100.

Damian MS, Hertel A, Seibel P, Reichmann H, Bachmann G, Schachenmayr W, Hoer G, Dorndorf W
Follow-up in carriers of the ‚MELAS‘ mutation without strokes.
Eur Neurol. 1998;39(1):9-15.
[PUBMED] [Abstract] [PDF]


Flierl A, Reichmann H, Seibel P
Pathophysiology of the MELAS 3243 transition mutation.
J Biol Chem. 1997 Oct 24;272(43):27189-96.
[PUBMED] [Abstract] [Full Text] [PDF]

Klopstock T, Naumann M, Seibel P, Shalke B, Reiners K, Reichmann H
Mitochondrial DNA mutations in multiple symmetric lipomatosis.
Mol Cell Biochem. 1997 Sep;174(1-2):271-5.
[PUBMED] [Abstract] [PDF]

Müller-Höcker J, Aust D, Rohrbach H, Napiwotzky J, Reith A, Link TA, Seibel P, Hölzel D, Kadenbach B
Defects of the respiratory chain in the normal human liver and in cirrhosis during aging.
Hepatology. 1997 Sep;26(3):709-19.
[PUBMED] [Abstract] [PDF]

Naumann M, Kiefer R, Toyka KV, Sommer C, Seibel P, Reichmann H
Mitochondrial dysfunction with myoclonus epilepsy and ragged-red fibers point mutation in nerve, muscle, and adipose tissue of a patient with multiple symmetric lipomatosis.
Muscle Nerve. 1997 Jul;20(7):833-9.
[PUBMED] [Abstract] [PDF]

Arends S, Schön A
Partial purification and characterization of nuclear ribonuclease P from wheat.
Eur J Biochem. 1997 Mar 1;244(2):635-45.
[PUBMED] [Abstract] [PDF]


Papa S, Scacco S, Schliebs M, Trappe J, Seibel P.
Mitochondrial diseases and aging.
Mol Aspects Med. 1996 Dec;17(6):513-63.

Müller-Höcker J, Aust D, Napiwotzky J, Münscher C, Link TA, Seibel P, Schneeweiss SG, Kadenbach B
Defects of the respiratory chain in oxyphil and chief cells of the normal parathyroid and in hyperfunction.
Hum Pathol. 1996 Jun;27(6):532-41.

Klopstock T, May A, Seibel P, Papagiannuli E, Diener HC, Reichmann H
Mitochondrial DNA in migraine with aura.
Neurology. 1996 Jun;46(6):1735-8.

Seibel P, Grünewald T, Gundolla A, Diener HC, Reichmann H
Investigation on the mitochondrial transfer RNA(Leu)(UUR) in blood cells from patients with cluster headache.
J Neurol. 1996 Apr;243(4):305-7.
[PUBMED] [Abstract] [PDF]

Baum M, Cordier A, Schön A
RNase P from a photosynthetic organelle contains an RNA homologous to the cyanobacterial counterpart.
J Mol Biol. 1996 Mar 22;257(1):43-52.
[PUBMED] [Abstract]

Baum M, Schön A
Localization and expression of the gene for RNase P from the Cyanophora paradoxa cyanelle.
FEBS Lett. 1996 Mar 11;382(1-2):60-4.
[PUBMED] [Abstract]

Oexle K, Oberle J, Finckh B, Kohlschütter A, Nagy M, Seibel P, Seissler J, Hübner C
Islet cell antibodies in diabetes mellitus associated with a mitochondrial tRNA(Leu(UUR)) gene mutation.
Exp Clin Endocrinol Diabetes. 1996;104(3):212-7.

Schön A
Ribonuclease P from plant nuclei and photosynthetic organelles.
Mol Biol Rep. 1995-1996;22(2-3):139-45.

Damian MS, Seibel P, Schachenmayr W, Reichmann H, Dorndorf W
VACTERL with the mitochondrial np 3243 point mutation.
Am J Med Genet. 1996 Apr 24;62(4):398-403.

Gold R, Seibel P, Reinelt G, Schindler R, Landwehr P, Beck A, Reichmann H
Phosphorus magnetic resonance spectroscopy in the evaluation of mitochondrial myopathies: results of a 6-month therapy study with coenzyme Q.
Eur Neurol. 1996;36(4):191-6.

Reichmann H, Vogler L, Seibel P
Ragged red or ragged blue fibers.
Eur Neurol. 1996;36(2):98-102.


Damian MS, Seibel P, Reichmann H, Schachenmayr W, Laube H, Bachmann G, Wassill KH, Dorndorf W
Clinical spectrum of the MELAS mutation in a large pedigree.
Acta Neurol Scand. 1995 Nov;92(5):409-15.

Barbiroli B, Medori R, Tritschler HJ, Klopstock T, Seibel P, Reichmann H, Iotti S, Lodi R, Zaniol P
Lipoic (thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P-MRS in a patient with mitochondrial cytopathy.
J Neurol. 1995 Jul;242(7):472-7.

Reichmann H, Schalke B, Seibel P, Naumann M, Toyka K
Sarcoid myopathy and mitochondrial respiratory chain defects: clinicopathological, biochemical and molecular biological analyses.
Neuromuscul Disord. 1995 Jul;5(4):277-83.
[PUBMED] [Abstract]

Seibel P, Trappe J, Villani G, Klopstock T, Papa S, Reichmann H
Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases.
Nucleic Acids Res. 1995 Jan 11;23(1):10-7.
[PUBMED] [Abstract] [PDF]

Klopstock T, Bischof F, Gerok K, Deuschl G, Seibel P, Ketelsen UP, Reichmann H
3.1-kb deletion of mitochondrial DNA in a patient with Kearns-Sayre syndrome.
Acta Neuropathol. 1995;90(2):126-9.


Müllges W, Dorn T, Paulus W, Seibel P, Reichmann H
A case of myoclonus epilepsy and lactic acidosis: difficulties in diagnosis and treatment of terminal mitochondrial cytopathy.
Intensive Care Med. 1994 Nov;20(8):613-4.

Seibel P, Lauber J, Klopstock T, Marsac C, Kadenbach B, Reichmann H
Chronic progressive external ophthalmoplegia is associated with a novel mutation in the mitochondrial tRNA(Asn) gene.
Biochem Biophys Res Commun. 1994 Oct 28;204(2):482-9.
[PUBMED] [Abstract]

Klopstock T, Naumann M, Schalke B, Bischof F, Seibel P, Kottlors M, Eckert P, Reiners K, Toyka KV, Reichmann H
Multiple symmetric lipomatosis: abnormalities in complex IV and multiple deletions in mitochondrial DNA.
Neurology. 1994 May;44(5):862-6.
[PUBMED] [Abstract] [PDF]

Seibel P, Flierl A, Kottlors M, Reichmann H
A rapid and sensitive PCR screening method for point mutations associated with mitochondrial encephalomyopathies.
Biochem Biophys Res Commun. 1994 Apr 29;200(2):938-42.
[PUBMED] [Abstract]

Damian MS, Reichmann H, Seibel P, Bachmann G, Schachenmayr W, Dorndorf W
[MELAS syndrome. Clinical aspects, MRI, biochemistry and molecular genetics].
Nervenarzt. 1994 Apr;65(4):258-63.

Mell OC, Seibel P, Kadenbach B
Structural organisation of the rat genes encoding liver- and heart-type of cytochrome c oxidase subunit VIa and a pseudogene related to the COXVIa-L cDNA.
Gene. 1994 Mar 25;140(2):179-86.
[PUBMED] [Abstract]

Stanzel M, Schön A, Sprinzl M
Discrimination against misacylated tRNA by chloroplast elongation factor Tu.
Eur J Biochem. 1994 Jan 15;219(1-2):435-9.
[PUBMED] [Abstract] [PDF]

Reichmann H, Janetzky B, Bischof F, Seibel P, Schöls L, Kuhn W, Przuntek H
Unaltered respiratory chain enzyme activity and mitochondrial DNA in skeletal muscle from patients with idiopathic Parkinson’s syndrome.
Eur Neurol. 1994;34(5):263-7.


Bonne G, Seibel P, Possekel S, Marsac C, Kadenbach B
Expression of human cytochrome c oxidase subunits during fetal development.
Eur J Biochem. 1993 Nov 1;217(3):1099-107.
[PUBMED] [Abstract] [Full Text] [PDF]

Schulz JB, Klockgether T, Dichgans J, Seibel P, Reichmann H
Mitochondrial gene mutations and diabetes mellitus.
Lancet. 1993 Feb 13;341(8842):438-9.
[PUBMED] [Abstract]

Reichmann H, Gold R, Meurers B, Naumann M, Seibel P, Walter U, Klopstock T
Progression of myopathology in Kearns-Sayre syndrome: a morphological follow-up study.
Acta Neuropathol. 1993;85(6):679-81.

Müller-Höcker J, Seibel P, Schneiderbanger K, Kadenbach B
Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly.
Virchows Arch A Pathol Anat Histopathol. 1993;422(1):7-15.


Müller-Höcker J, Seibel P, Schneiderbanger K, Zietz C, Obermaier-Kusser B, Gerbitz KD, Kadenbach B
In situ hybridization of mitochondrial DNA in the heart of a patient with Kearns-Sayre syndrome and dilatative cardiomyopathy.
Hum Pathol. 1992 Dec;23(12):1431-7.

Schön A, Gough S, Söll D
Chloroplast tRNAAsp: Nucleotide sequence and variation of in vivo levels during plastid maturation.
Plant Mol Biol. 1992 Nov;20(4):601-7.

Schön A, Rokem JS.
Misaminoacylation and tRNA-dependent transamidation in Streptomyces coelicolor A3(2).
FEMS Microbiol. Lett. 1992 Apr; 9(1):19-22.
[Abstract] [PDF]

Grawunder U, Schön A, Sprinzl M
Sequence and base modification of two phenylalanine tRNAs from Thermus thermophilus HB8.
Nucleic Acids Res. 1992 Jan 11;20(1):137.


Seibel P, Degoul F, Bonne G, Romero N, François D, Paturneau-Jouas M, Ziegler F, Eymard B, Fardeau M, Marsac C, Kadenbach B
Genetic biochemical and pathophysiological characterization of a familial mitochondrial encephalomyopathy (MERRF).
J Neurol Sci. 1991 Oct;105(2):217-24.
[PUBMED] [Full Text]

Sprinzl M, Dank N, Nock S, Schön A
Compilation of tRNA sequences and sequences of tRNA genes.
Nucleic Acids Res. 1991 Apr 25;19 Suppl:2127-71.

Lauber J, Marsac C, Kadenbach B, Seibel P
Mutations in mitochondrial tRNA genes: a frequent cause of neuromuscular diseases.
Nucleic Acids Res. 1991 Apr 11;19(7):1393-7.


Seibel P, Degoul F, Romero N, Marsac C, Kadenbach B
Identification of point mutations by mispairing PCR as exemplified in MERRF disease.
Biochem Biophys Res Commun. 1990 Dec 14;173(2):561-5.
[PUBMED] [Abstract]

Wallace DC, Lott MT, Lezza AM, Seibel P, Voljavec AS, Shoffner JM
Mitochondrial DNA mutations associated with neuromuscular diseases: analysis and diagnosis using the polymerase chain reaction.
Pediatr Res. 1990 Nov;28(5):525-8.

O’Neill GP, Schön A, Chow H, Chen MW, Kim YC, Söll D
Sequence of tRNAGlu and its genes from the chloroplast genome of Chlamydomonas reinhardtii.
Nucleic Acids Res. 1990 Oct 11;18(19):5893.

Rokem JS, Schön A, Söll D
Sequence of a tRNAGly from Streptomyces coelicolor.
Nucleic Acids Res. 1990 Jul 11;18(13):3988.

Shoffner JM, Lott MT, Lezza AM, Seibel P, Ballinger SW, Wallace DC
Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation.
Cell. 1990 Jun 15;61(6):931-7.
[PUBMED] [Abstract]

Chen MW, Jahn D, Schön A, O’Neill GP, Söll D
Purification and characterization of Chlamydomonas reinhardtii chloroplast glutamyl-tRNA synthetase, a natural misacylating enzyme.
J Biol Chem. 1990 Mar 5;265(7):4054-7.

Rokem JS, Schön A, Söll D
Isolation and Sequence of a tRNAGly (CCC) from Streptomyces coelicolor A3(2). In: Genetics and product formation in Streptomyces.
Noack, D., Krugel, H. and Baumberg, S. (eds). 1990. Plenum, London, pp. 47-52.


Schön A, Böck A, Ott G, Sprinzl M, Söll D
The selenocysteine-inserting opal suppressor serine tRNA from E. coli is highly unusual in structure and modification.
Nucleic Acids Res. 1989 Sep 25;17(18):7159-65.

Schön A, O’Neill GP, Peterson DM, Söll D
Glutamyl-tRNAs from chloroplasts as cofactors in non-ribosomal enzymatic reactions.
In: Molecular Biology of RNA. Cech, T. (ed.) Alan R. 1989. Liss, Inc.: pp. 271-278.


Schön A, Söll D
Dual role of glutamyl-tRNA in barley chloroplasts: Involvement in chlorophyll and protein biosynthesis.
Arch Biol Med Exp (Santiago).1988 Dec;21(3-4):467-73.

O’Neill GP, Peterson DM, Schön A, Chen MW, Söll D
Formation of the chlorophyll precursor δ-aminolevulinic acid in cyanobacteria requires aminoacylation of a tRNAGlu species.
J Bacteriol. 1988 Sep;170(9):3810-6.

Peterson DM, Schön A, Söll D
The nucleotide sequences of barley cytoplasmic glutamate transfer RNAs and structural features essential for formation of δ-aminolevulinic acid.

Plant Mol Biol. 1998 May;11(3):293-9.
[Abstract] [PDF]

Schön A, Hottinger H, Söll D
Misaminoacylation and transamidation are required for protein biosynthesis in Lactobacillus bulgaricus.
Biochimie. 1988 Mar;70(3):391-4.

Schön A, Söll D
Transfer RNA specificity of a mischarging aminoacyl tRNA synthetase: Glutamyl tRNA synthetase from barley chloroplasts.
FEBS Lett. 1988 Feb 15;228(2):241-4.

Schön A, Kannangara CG, Gough S, Söll D
Protein biosynthesis in organelles requires misaminoacylation of transfer RNA.
Nature. 1988 Jan 14;331(6152):187-90.


Schön A
Sequence of a isoleucine tRNA from Mycoplasma mycoides sp. Capri.
Nucleic Acids Res. 1987 Jul 10;15(13):5488

Schön, A., Krupp, G., Gough, S., Kannangara, C.G., and Söll, D. (1987).
A new role for transfer RNA: A chloroplast tRNA is a cofactor in the conversion of glutamate to δ-aminolevulinic acid.
In: Molecular Biology of RNA: New Perspectives. Inouye, M. and Dudock, B.S. (eds.). 1987. Academic Press Inc., Orlando, Fla.: pp. 295-303.


Schön A, Krupp G, Gough S, Berry-Lowe S, Kannangara CG, Söll D
The RNA required in the first step of chlorophyll biosynthesis is a chloroplast glutamate tRNA.
Nature. 1986 Jul 17-23;322(6076):281-4.
[PUBMED] [Abstract] [PDF]


Schön A, Mundry KW
Coordinated two-disk nucleation, growth and properties of virus-like particles assembled from Tobacco Mosaic Virus capsid protein with poly (A) or oligo (A) of different lengths.
Eur J Biochem. 1984 Apr 2;140(1):119-27.
[PUBMED] [Abstract] [PDF]