The relationship of HPA axis activity, autonomous activity, and aggressive behavior

Khan, R.¹, Bertsch, K.¹, Kruk, M. R.², and Naumann, E.^1
1Department of Psychology, University of Trier; ²Department of Medical Pharmacology, Leiden University

Results from studies with animals and clinical samples in humans suggest that low basal arousal as well as increased acute autonomous and HPA axis activity are related to enhanced aggressive behavior. We therefore pharmacologically enhanced cortisol levels in 28 healthy subjects by administering 20mg of hydrocortisone (stress group), 28 others were given a placebo (placebo group). We then induced aggressive behavior with the Taylor Aggression Paradigm in half of the stress and the placebo group, respectively. Aggressive behavior between the groups was compared. We furthermore analyzed the relationship of basal HPA axis activity, which was measured prior to the experiment, and aggression. Autonomous measures were assessed in baseline conditions and during the induction of aggression. Results are discussed within the framework of low basal arousal and enhanced reactivity in aggressive subjects and put into context to evidence from animals and clinical and experimental studies in humans.

Symposium 18: Biology of Aggression
12.06.2009, 14:00-15:00
Hörsaal Nord