Postersession 1
Poster #: 46
Topic: Diagnostics and inter-individual differences
Wednesday, Sep 9, 2015
17:00-18:30
1st floor

Resting-state glutamatergic neurotransmission is related to the peak latency of auditory MMN for duration deviants

Kristiina Kompus¹, Kairi Kreegipuu, Nele Põldver², René Westerhausen, Kenneth Hugdahl, & Risto Näätänen

¹Bergen, Norway
²Department of Psychology, University of Tartu, Tartu, Estonia
kristiina.kompus@psybp.uib.no

Mismatch negativity (MMN) has been suggested to be associated to glutamatergic neurotransmission, mediated by glutamatergic NMDA receptors. In this study we used magnetic resonance spectroscopy (MRS), a non-invasive brain imaging method which allows quantification of metabolites in vivo to examine the relationship between inter-individual variation of 1H-MRS-measured glutamate+glutamine (Glx) in the superior temporal gyrus, and MMN for duration and frequency deviants in 19 healthy young adults (9 male). The peak latency of the duration-MMN peak was associated with Glx (p=.0003, η2=.43), with increased Glx level being associated to earlier peak of the duration-MMN (r= -.63). In contrast, the amplitude of the duration-MMN was not related to Glx. There was no significant relationship between Glx and the frequency-MMN. We conclude that the inter-individual variation in the glutamatergic neurotransmission affects the MMN response in healthy individuals.