Poster #: 46
Topic: Diagnostics and inter-individual differences
Wednesday, Sep 9, 2015
Resting-state glutamatergic neurotransmission is related to the peak latency of auditory MMN for duration deviants
2Department of Psychology, University of Tartu, Tartu, Estonia
Mismatch negativity (MMN) has been suggested to be associated to glutamatergic neurotransmission, mediated by glutamatergic NMDA receptors. In this study we used magnetic resonance spectroscopy (MRS), a non-invasive brain imaging method which allows quantification of metabolites in vivo to examine the relationship between inter-individual variation of 1H-MRS-measured glutamate+glutamine (Glx) in the superior temporal gyrus, and MMN for duration and frequency deviants in 19 healthy young adults (9 male). The peak latency of the duration-MMN peak was associated with Glx (p=.0003, η2=.43), with increased Glx level being associated to earlier peak of the duration-MMN (r= -.63). In contrast, the amplitude of the duration-MMN was not related to Glx. There was no significant relationship between Glx and the frequency-MMN. We conclude that the inter-individual variation in the glutamatergic neurotransmission affects the MMN response in healthy individuals.