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PeopleAlumniDr.
Jochen Guck
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Dr. Jochen Guck
Former Academic Staff |
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Jochen Guck left the Soft Matter Physics Division in December
2006 and became principal investigator of a new research group at the Cavendish
Laboratory ot the University of Cambridge. |
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new location:
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University of Cambridge
Cavendish Laboratory
Biological and Soft Systems (BSS)
J.J. Thomson Avenue, Cambridge CB3 0HE, United Kingdom |
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phone:
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+44 1223 748914 |
fax:
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+44 1223 337000 |
e-mail:
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website:
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www.bss.phy.cam.ac.uk/~jg473/ |
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Education |
1993 |
Abitur, Gymnasium Bad Königshofen |
1995 |
Vordiplom, Physics, Julius Maximilians Universität Würzburg |
1997 |
M.A., Physics, University of Texas at Austin, USA |
2001 |
PhD, Physics, University of Texas at Austin, USA |
2002-2006 |
Habilitation, Physics, University of Leipzig |
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Professional Experience |
1996 - 2001 |
Graduate Research Assistant, University of Texas at Austin,
USA |
08/2000 - 12/2000 |
Teaching Assistant, University of Texas at Austin, USA |
2000 - present |
Consultant for EMD Technologies, Inc., Austin, Texas, USA |
01/2002 - 04/2002 |
Wissenschaftlicher Mitarbeiter, University of Leipzig |
05/2002 - 12/2006 |
Nachwuchsgruppenleiter (Wissenschaftlicher Assistent), University
of Leipzig |
Awards and Fellowships |
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1996-1997 Auslandsstipendium, Deutscher Akademischer Auslandsdienst
(DAAD)
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2001 Professional Development Award, University of Texas at Austin,
USA
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2003 "Young Scientist Award in Biomedical Photonics" by Hamamatsu
and the German Cancer Research Center (DKFZ, Heidelberg)
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Patents |
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US Patent No. 6,067,859 "Optical Stretcher" (May 30, 2000). Inventors:
Josef Käs and Jochen Guck.
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European Patent #99909852.8-2305 "Optical Stretcher" (November 2000) for
Germany, Great Britain, France, Switzerland, Italy, Spain.
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Research Interests and Expertise |
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Biophysics and biological physics, laser physics, soft condensed
matter physics, neuroscience, complex fluids, molecular biology, nonlinear
dynamics, nonlinear optics
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Optical micromanipulation and -rheology on individual cells
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Optical deformability of cells as inherent cell marker for diagnosis
of cancer and other diseases
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Soft-lithography based microfluidic systems ("lab-on-a-chip")
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Medical, regenerative applications of pluripotent stem cells
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Nerve development, regeneration, and plasticity in the central nervous
system
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Glasses and gels in colloidal and polymer systems
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Publications |
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T. W. Remmerbach, F. Wottawah, J. Dietrich, B. Lincoln, C. Wittekind, J.
Guck: Oral Cancer Diagnosis by Mechanical Phenotyping,
Cancer Research 69(5):1728-1732 (2009)
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M. K. Kreysing, T. Kießling, A. Fritsch, C. Dietrich, J. R. Guck,
J. A. Käs: The optical cell rotator,
Optics Express 16(21):16984-16992 (2008)
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K. Franze, J. Grosche, S. N. Skatchkov, S. Schinkinger, C. Foja, D. Schild,
O. Uckermann, K. Travis, A. Reichenbach, J. Guck: Müller
cells are living optical fibers in the vertebrate retina, PNAS 104(20):8287-8292
(2007)
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B. Lincoln, S. Schinkinger, K. Travis, F. Wottawah, S. Ebert, F. Sauer,
J. Guck: Reconfigurable microfluidic integration
of a dual-beam laser trap with biomedical applications, Biomedical
Microdevices 9(5):703-710 (2007)
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S. Ebert, K. Travis, B. Lincoln, J. Guck: Fluorescence
ratio thermometry in a microfluidic dual-beam laser trap, Optics
Express 15(23):15493-15499 (2007)
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K. Travis, J. Guck: Scattering from Single
Nanoparticles: Mie Theory Revisited, Biophys. Rev. Lett. 1(2):179-207
(2006)
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F.-U. Gast, P. S. Dittrich, P. Schwille, M. Weigel, M. Mertig, J. Opitz,
U. Queitsch, S. Diez, B. Lincoln, F. Wottawah, S. Schinkinger, J. Guck,
J. Käs, J. Smolinski, K. Salchert, C. Werner, C. Duschl, M. S. Jäger,
K. Uhlig, P. Geggier, S. Howitz: The microscopy
cell (MicCell), a versatile modular flowthrough system for cell biology,
biomaterial research, and nanotechnology, Microfluid. Nanofluid.
2(1):21-36 (2006)
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R. Ananthakrishnan, J. Guck, F. Wottawah, S. Schinkinger, B. Lincoln, M.
Romeyke, T. Moon, J. Käs: Quantifying
the contribution of actin networks to the elastic strength of fibroblasts,
J. Theo. Biol. 242(2):502-516 (2006)
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Y.-B. Lu, K. Franze, G. Seifert, C. Steinhäuser, F. Kirchhoff, H.
Wolburg, J. Guck, P. Janmey, E.-Q. Wei, J. Käs, A. Reichenbach: Viscoelastic
properties of individual glial cells and neurons in the CNS, PNAS
103(47):17759-17764 (2006)
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F. Wottawah, S. Schinkinger, B. Lincoln, R. Ananthakrishnan, M. Romeyke,
J. Guck, J. Käs: Optical rheology of biological
cells, Phys. Rev. Lett. 94(9):98103 (2005)
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J. Guck, H. Erickson, R. Ananthakrishnan, D. Mitchell, M. Romeyke, S. Schinkinger,
F. Wottawah, B. Lincoln, J. Käs, S. Ulvick, C. Bilby: Optical
Deformability as Inherent Cell Marker for Malignant Transformation and
Metastatic Competence, Biophys. J. 88(5):3689-98 (2005)
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R. Ananthakrishnan, J. Guck, F. Wottawah, S. Schinkinger, B. Lincoln, M.
Romeyke, J. Käs: Modelling the structural
response of an eukaryotic cell in the optical stretcher, Current
Science 88(9):1434 (2005)
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T. Betz, J. Teipel, D. Koch, W. Härtig, J. Guck, J. Käs, H. Giessen: Excitation
beyond the monochromatic laser limit: Simultaneous 3-D confocal and multiphoton
microscopy with a tapered fiber as white-light laser source, J Biomed
Optics 10(5):054009 (2005)
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F. Wottawah, S. Schinkinger, B. Lincoln, S. Ebert. K. Müller, F. Sauer,
K. Travis, J. Guck: Characterizing Single Suspended
Cells by Optorheology, Acta Biomat. 1(3):263-271 (2005)
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B. Lincoln, H. M.Erickson, S. Schinkinger, F. Wottawah, D. Mitchell, S.
Ulvick, C. Bilby, J. Guck: Deformability-Based
Flow Cytometry, Cytometry Part A 59A:203-209 (2004)
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S. Schinkinger, K.A. Travis, F. Wottawah, B. Lincoln, J. Guck: Feeling
for Cells with Light, Proceedings of SPIE: Optical Trapping and
Optical Micromanipulation 5514:170-178 (2004)
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J. Guck, R. Ananthakrishnan, C.C. Cunningham, J. Käs: Stretching
biological cells with light, J. Phys. Cond. Matter 14(19):4843 (2002)
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J. Guck, R. Ananthakrishnan, T. J. Moon, C. C. Cunningham, J. Käs: The
Optical Stretcher: A Novel Laser Tool to Micromanipulate Cells,
Biophys. J. 81(2):767-784 (2001)
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J. Guck: Optical Deformability-Micromechanics
from Cell Research to Biomedicine, PhD dissertation, University
of Texas at Austin, USA (2001)
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J. Guck, R. Ananthakrishnan, T.J. Moon, C.C. Cunningham, J. Käs: Optical
deformability of soft dielectric materials, Phys. Rev. Lett. 84(23):5451-5454
(2000)
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J. Käs, J. Guck, D. Humphrey: Dynamics
of Single Protein Polymers Visualized by Fluorescence Microscopy,
Modern Optics, Electronics and High Precision Techniques in Cell Biology,
ed. by G. Isenberg, Springer Verlag, 103-137 (1997)
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