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Soft Matter Physics Division - Biophysics at the University of Leipzig University of Leipzig
PeopleAlumniDr. Jochen Guck
 
 
Dr. Jochen Guck
Former Academic Staff
Jochen Guck left the Soft Matter Physics Division in December 2006 and became principal investigator of a new research group at the Cavendish Laboratory ot the University of Cambridge.
new location:
University of Cambridge
Cavendish Laboratory
Biological and Soft Systems (BSS)
J.J. Thomson Avenue, Cambridge CB3 0HE, United Kingdom
phone:
+44 1223 748914
fax:
+44 1223 337000
e-mail:
website:
www.bss.phy.cam.ac.uk/~jg473/
Education
1993 Abitur, Gymnasium Bad Königshofen
1995 Vordiplom, Physics, Julius Maximilians Universität Würzburg
1997 M.A., Physics, University of Texas at Austin, USA
2001 PhD, Physics, University of Texas at Austin, USA
2002-2006 Habilitation, Physics, University of Leipzig
 
Professional Experience
1996 - 2001 Graduate Research Assistant, University of Texas at Austin, USA
08/2000 - 12/2000 Teaching Assistant, University of Texas at Austin, USA
2000 - present Consultant for EMD Technologies, Inc., Austin, Texas, USA
01/2002 - 04/2002 Wissenschaftlicher Mitarbeiter, University of Leipzig
05/2002 - 12/2006 Nachwuchsgruppenleiter (Wissenschaftlicher Assistent), University of Leipzig

 
Awards and Fellowships
  • 1996-1997 Auslandsstipendium, Deutscher Akademischer Auslandsdienst (DAAD)
  • 2001 Professional Development Award, University of Texas at Austin, USA
  • 2003 "Young Scientist Award in Biomedical Photonics" by Hamamatsu and the German Cancer Research Center (DKFZ, Heidelberg)
 
Patents
  • US Patent No. 6,067,859 "Optical Stretcher" (May 30, 2000). Inventors: Josef Käs and Jochen Guck.
  • European Patent #99909852.8-2305 "Optical Stretcher" (November 2000) for Germany, Great Britain, France, Switzerland, Italy, Spain.
 
Research Interests and Expertise
  • Biophysics and biological physics, laser physics, soft condensed matter physics, neuroscience, complex fluids, molecular biology, nonlinear dynamics, nonlinear optics
  • Optical micromanipulation and -rheology on individual cells
  • Optical deformability of cells as inherent cell marker for diagnosis of cancer and other diseases
  • Soft-lithography based microfluidic systems ("lab-on-a-chip")
  • Medical, regenerative applications of pluripotent stem cells
  • Nerve development, regeneration, and plasticity in the central nervous system
  • Cells as light guides
  • Glasses and gels in colloidal and polymer systems
 
Publications
  • T. W. Remmerbach, F. Wottawah, J. Dietrich, B. Lincoln, C. Wittekind, J. Guck: Oral Cancer Diagnosis by Mechanical Phenotyping, Cancer Research 69(5):1728-1732 (2009)
  • M. K. Kreysing, T. Kießling, A. Fritsch, C. Dietrich, J. R. Guck, J. A. Käs: The optical cell rotator, Optics Express 16(21):16984-16992 (2008)
  • K. Franze, J. Grosche, S. N. Skatchkov, S. Schinkinger, C. Foja, D. Schild, O. Uckermann, K. Travis, A. Reichenbach, J. Guck: Müller cells are living optical fibers in the vertebrate retina, PNAS 104(20):8287-8292 (2007)
  • B. Lincoln, S. Schinkinger, K. Travis, F. Wottawah, S. Ebert, F. Sauer, J. Guck: Reconfigurable microfluidic integration of a dual-beam laser trap with biomedical applications, Biomedical Microdevices 9(5):703-710 (2007)
  • S. Ebert, K. Travis, B. Lincoln, J. Guck: Fluorescence ratio thermometry in a microfluidic dual-beam laser trap, Optics Express 15(23):15493-15499 (2007)
  • K. Travis, J. Guck: Scattering from Single Nanoparticles: Mie Theory Revisited, Biophys. Rev. Lett. 1(2):179-207 (2006)
  • F.-U. Gast, P. S. Dittrich, P. Schwille, M. Weigel, M. Mertig, J. Opitz, U. Queitsch, S. Diez, B. Lincoln, F. Wottawah, S. Schinkinger, J. Guck, J. Käs, J. Smolinski, K. Salchert, C. Werner, C. Duschl, M. S. Jäger, K. Uhlig, P. Geggier, S. Howitz: The microscopy cell (MicCell), a versatile modular flowthrough system for cell biology, biomaterial research, and nanotechnology, Microfluid. Nanofluid. 2(1):21-36 (2006)
  • R. Ananthakrishnan, J. Guck, F. Wottawah, S. Schinkinger, B. Lincoln, M. Romeyke, T. Moon, J. Käs: Quantifying the contribution of actin networks to the elastic strength of fibroblasts, J. Theo. Biol. 242(2):502-516 (2006) 
  • Y.-B. Lu, K. Franze, G. Seifert, C. Steinhäuser, F. Kirchhoff, H. Wolburg, J. Guck, P. Janmey, E.-Q. Wei, J. Käs, A. Reichenbach: Viscoelastic properties of individual glial cells and neurons in the CNS, PNAS 103(47):17759-17764 (2006)
  • F. Wottawah, S. Schinkinger, B. Lincoln, R. Ananthakrishnan, M. Romeyke, J. Guck, J. Käs: Optical rheology of biological cells, Phys. Rev. Lett. 94(9):98103 (2005)
  • J. Guck, H. Erickson, R. Ananthakrishnan, D. Mitchell, M. Romeyke, S. Schinkinger, F. Wottawah, B. Lincoln, J. Käs, S. Ulvick, C. Bilby: Optical Deformability as Inherent Cell Marker for Malignant Transformation and Metastatic Competence, Biophys. J. 88(5):3689-98 (2005)
  • R. Ananthakrishnan, J. Guck, F. Wottawah, S. Schinkinger, B. Lincoln, M. Romeyke, J. Käs: Modelling the structural response of an eukaryotic cell in the optical stretcher, Current Science 88(9):1434 (2005)
  • T. Betz, J. Teipel, D. Koch, W. Härtig, J. Guck, J. Käs, H. Giessen: Excitation beyond the monochromatic laser limit: Simultaneous 3-D confocal and multiphoton microscopy with a tapered fiber as white-light laser source, J Biomed Optics 10(5):054009 (2005)
  • F. Wottawah, S. Schinkinger, B. Lincoln, S. Ebert. K. Müller, F. Sauer, K. Travis, J. Guck: Characterizing Single Suspended Cells by Optorheology, Acta Biomat. 1(3):263-271 (2005)
  • B. Lincoln, H. M.Erickson, S. Schinkinger, F. Wottawah, D. Mitchell, S. Ulvick, C. Bilby, J. Guck: Deformability-Based Flow Cytometry, Cytometry Part A 59A:203-209 (2004)
  • S. Schinkinger, K.A. Travis, F. Wottawah, B. Lincoln, J. Guck: Feeling for Cells with Light, Proceedings of SPIE: Optical Trapping and Optical Micromanipulation 5514:170-178 (2004)
  •  J. Guck, R. Ananthakrishnan, C.C. Cunningham, J. Käs: Stretching biological cells with light, J. Phys. Cond. Matter 14(19):4843 (2002)
  • J. Guck, R. Ananthakrishnan, T. J. Moon, C. C. Cunningham, J. Käs: The Optical Stretcher: A Novel Laser Tool to Micromanipulate Cells, Biophys. J. 81(2):767-784 (2001)
  •  J. Guck: Optical Deformability-Micromechanics from Cell Research to Biomedicine, PhD dissertation, University of Texas at Austin, USA (2001)
  •  J. Guck, R. Ananthakrishnan, T.J. Moon, C.C. Cunningham, J. Käs: Optical deformability of soft dielectric materials, Phys. Rev. Lett. 84(23):5451-5454 (2000)
  •  J. Käs, J. Guck, D. Humphrey: Dynamics of Single Protein Polymers Visualized by Fluorescence Microscopy, Modern Optics, Electronics and High Precision Techniques in Cell Biology, ed. by G. Isenberg, Springer Verlag, 103-137 (1997)
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