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Aim of meeting:
The investigation of changes in physical properties of cells during
malignant transformation is an emerging field in current cancer research
and cell biology. Recent findings in this new field obtained that the biomechanical
properties of tumor cells promote their growth as well as their invasion
within the human body. Several biomechanical properties are in the focus
of these observations, such as: First, the actin cortex of cancer cells
is much softer and supports fast growth and cell division. Second, although
the actin cortex softens, it can resist high pressures exerted from the
surroundings which supports tumor growth into the surrounding tissue. In
return, elements of the cytoskeleton are pronounced which results in an
overall stiffening of the tumor. These new insights could give rise to
a better understanding how and why some cancer cells get the ability to
metastasize and invade into the human body.
Topics included:
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Biomechanics (Biopolymers, Networks, Rheology, Cytoskeleton, Cell Shape)
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Forces, Motion, Adhesion (Cell Motility, Assembly, Molecular Motors, Cell
Division)
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Oncology
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Imaging
Chairs:
Prof.
Dr. Josef A. Käs
University of Leipzig
E-Mail:
Prof.
Dr. Harald Herrmann
German Cancer Research Center, Heidelberg
E-Mail:
Prof.
Dr. Sarah Köster
Georg August University of Göttingen
E-Mail:
Invited speakers:
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Aebi,
Ueli (University of Basel, Switzerland)
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Bausch,
Andreas (Technical University Munich, Germany)
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Beck-Sickinger,
Annette (University of Leipzig, Germany)
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Beil, Michael (University of Ulm, Germany)
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Condeelis,
John (Albert Einstein College of Medicine of Yeshiva University, USA)
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Elgeti,
Jens (Institut Curie, France)
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Falcke,
Martin (Max-Delbrück-Center for Molecular Medicine, Germany)
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Grill,
Stefan (Max Planck Institute of Molecular Cell Biology and Genetics,
Germany)
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Guck,
Jochen (University of Cambridge, UK)
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Horn,
Lars-Christian (University of Leipzig, Germany)
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Kemkemer,
Ralf (Max Planck Institute for Intelligent Systems, Germany)
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Losert, Wolfgang
(University of Maryland, USA)
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Martin,
Stuart (University of Maryland, USA)
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Mierke,
Claudia (University of Leipzig, Germany)
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Paluch,
Ewa (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
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Radmacher,
Manfred (University of Bremen, Germany)
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Vignjevic,
Danijela (Institut Curie, France)
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Weitz, David
(Harvard University, USA)
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Wirtz, Denis
(Johns Hopkins University, USA)
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Wolf,
Katarina (Radboud University Nijmegen, Netherlands)
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Zink,
Mareike (University of Leipzig, Germany)
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