Stephan W. Grill
 

Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany

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I will present recent advances in our understanding of the coupling of mechanical and biochemical processes for the purpose of forming intracellular patterns. I will begin by discussing in general terms the mechanism of pattern formation in active fluids in which active stress is regulated by diffusing molecular components. I will then discuss a particular biological example, which is the polarization of the C. elegans zygote, a classic example for mechanochemical coupling. I illustrate how passive advection by actively generated fluid flow is sufficient to drive asymmetry in PAR proteins and thereby acts as a trigger for pattern formation. Our work suggests that passive advective transport in a regulated active material is a general mechanism by which patterns are established in developmental biology.