Michael Beil
 

University of Ulm, University Hospital, Center for Internal Medicine, Clinic for Internal Medicine I, Albert-Einstein-Allee 23, 89081 Ulm, Germany

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The fundamental role of the cytoskeleton for regulating cell shape and mechanics has been emphasized by a large number of experimental studies. Cytoskeletal filament systems could become a prime target for blocking cancer cell migration. However, the success story of taxol targeting microtubules in-vivo has not been duplicated so far by developing clinically useful agents which interfere with other filament systems. The particular contributions of and the interplay between the major components of the cytoskeleton remain to be elucidated in more detail. This talk will discuss new developments in this field and demonstrate strategies to target cancer cell motility.