Mike Lange

  • Position: PhD Student
  • Email: mike.lange(at)uni-leipzig.de
  • Phone: +49 (0) 341 97 31 334
Research project:
 My research aims at the identification and quantification of oxidized lipid species and their corresponding protein adducts in adipose tissue of insulin resistant and insulin sensitive patients. By putting the obtained omics data in a systems medicine environment, an integrated view on obesity and obesity related complications can be provided with the final goal of identifying potential biomarkers and therapeutic targets with high diagnostic, prognostic and therapeutic potential.
mitarbeiter_mikelange_research
Education:
PhD Study (since 2016), Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Germany
PhD thesis “Integration of oxidative stress into systems medicine view for obesity and obesity related complications”
Master of Science (2013-2015), Friedrich-Alexander Universität Erlangen-Nürnberg
Master thesis “Mechanistic Investigation of the oxPTM S-Sulfhydration”
Bachelor of Science (2010-2013), Friedrich-Alexander Universität Erlangen‑Nürnberg
Bachelor thesis “Synthesis of Triazole-Based PHD2 Inhibitors by Click-Chemistry”
Semester Abroad (2014), University College Dublin
Training and Studies in Biochemistry and Medicinal Chemistry
Publications:
  • Cuevasanta, M. Lange, J. Bonanata, E. L. Coitino, G. Ferrer-Sueta, M. R. Filipovic, B. Alvarez, “Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide”, J. Biol. Chem., 2015, 290(45) 26866-80.
  • Wedmann, C. Onderka, S. Wie, I. A. Szijarto, J. L. Miljkovic, A. Mitrovic, M. Lange, S. Savitsky, P. K. Yadav, R. Torregrossa, E. G. Harrer, T. Harrer, I. Ishii, M. Gollasch, M. E. Wood, E. Galardon, M. Xian, M. Whiteman, R. Banerjee, M. R. Filipovic, “Improved Tag-Switch Method Reveals that Thioredoxin Acts as Depersulfidase and Controls Intracellular Levels of Protein Persulfidation”, Chem. Sci., 2016, 7: 3414-26.