The project focuses on cell culture models of oxidative stress (primary cardiomyocytes, epithelial cell and THP1). I use LC-MS/MS techniques to identify oxidized lipids and lipid-protein adducts in cellular extracts. Using complimentary techniques (fluorescent microscopy and biochemical assays) I am going to study how oxidation can cause changes in cellular localization and functions of target lipids and protein.
PhD study (since 2016) Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Germany
PhD thesis: “Identification and validation of modified lipids and proteins targets in cellular models of oxidative stress”