My project aims to integrate Omics data on lipid peroxidation products (LPPs) and their protein adducts into systems medicine view on obesity and related complications. I will use clinical and Omics data for statistical evaluation, networks analysis and mathematical modeling to understand a role of oxidative stress and LPPs in disease onset and progression. We are constantly collecting data from our experiments as well as publically available datasets on various LPPs to be integrated in LPPdb, a first knowledge database on oxidized lipids. LPPdb will provide a platform to scientists from academia, clinics and industry to support the identification of different LPP species form high-throughput lipidomics for biomarker discovery and validation and thus help to determine "biomarker signatures" to assess pathological processes. Furthermore, we are working on development and optimization of software tools for high-throughput identification of oxidized lipids from LC-MS/MS data.
PhD student: Since 10/2016: Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Germany
Master in Bioinformatics (09/2013-06/2015), Lund University
Master thesis: “Evolution of Major Histocompatibility Complex (MHC) genes in songbirds. Development of a database and phylogenetic analysis of the gene for the different species”
Bachelor in Biological Sciences (09/2008-06/2012), University of Cyprus
Bachelor’s thesis: “SGAcruncher: Development of a prototype software for data analysis using the experiments of Synthetic Genetic Array (SGA) analysis .”
1st Poster Prize on International HNE Club Meeting, 09, 2017, Graz, Austria
Zhixu Ni, Georgia Angelidou, Ralf Hoffmann, and Maria Fedorova. . "LPPtiger software for lipidome-specific prediction and identification of oxidized phospholipids from LC-MS datasets." Scientific Reports 7, Article number: 15138.
Zhixu Ni, Georgia Angelidou, Mike Lange, Ralf Hoffmann, and Maria Fedorova. "LipidHunter Identifies Phospholipids by High-Throughput Processing of LC-MS and Shotgun Lipidomics Datasets." Analytical Chemistry 89 (17), pp 8800–8807.
Dimitris Kyriakou, Emmanouil Stavrou, Panayiota Demosthenous, Georgia Angelidou, Bryan-Joseph San Luis, Charles Boone, Vasilis J. Promponas and Antonis Kirmizis. "Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae." BMC Biology 2016 14:106.