Our research aims to understand molecular effects of reactive oxygen and nitrogen species (ROS/RNS) in onset and development of numerous human pathologies including cardiovascular and metabolic diseases (in particular obesity and type 2 diabetes). Elevated ROS/RNS levels result in oxidative modifications of main cellular biomolecules including lipids and proteins.
We are working on development and applications of modern bioanalytical techniques (chromatography and high resolution mass spectrometry) for detection and quantification of low abundant modified lipids and proteins in complex biological samples.
Availability of large multi-Omics datasets in combination with functional biochemical assays allows us to integrate data on oxidized lipids and proteins using systems biology/systems medicine environment in order to understand effects of oxidative modifications in pathogenesis of human disorders.
List of our current projectsAll projects
List of our recent publications
Zhixu Ni, Georgia Angelidou, Ralf Hoffmann, Maria Fedorova
Zhixu Ni, Georgia Angelidou, Mike Lange, Ralf Hoffmann, Maria Fedorova
Eva Griesser, Venukumar Vemula, Nora Raulien, Ulf Wagner, Sandra Reeg, Tilman Grune, Maria Fedorova
Venukumar Vemula, Zhixu Ni, Maria Fedorova
Zhixu Ni, Ivana Milic, Maria Fedorova