Depth ERPs and fMRI comparative study of auditory oddball task

Brazdil, M.1, Dobsik, M.1,2, Mikl, M.1, Daniel, P.1, Pazourkova, M.3, Krupa, P.3, and Rektor, I.1
1Department of Neurology, St. Anne University Hospital, Brno, Czech Republic; 2Faculty of Information Technology, Brno University of Technology, Czech Republic; 3Department of Neuroimaging, St. Anne University Hospital, Brno, Czech Republic

Event-related fMRI (efMRI) was repeatedly used to seek the neural sources of endogenous event-related potentials (ERP). Significant discrepancies between the efMRI data and the results of previously published intracranial ERP studies of oddball task were revealed.

To evaluate the capacity of efMRI to define the sources of the P3 component of ERP within the human brain, both efMRI and intracerebral ERP recordings were performed in eight patients with intractable epilepsy (five males and three females) during their preoperative invasive video-EEG monitoring. An identical auditory oddball task with frequent and target stimuli was completed in two sessions. A total of 606 intracerebral sites were electrophysiologically investigated by means of depth electrodes.

In accordance with the finding of multiple intracerebral generators of P3 potential, the target stimuli evoked MRI signal increase in multiple brain regions. However, regions with evident hemodynamic and electrophysiological responses overlapped only partially. A P3 generator was always found within a hemodynamic-active site, if this site was investigated by means of depth electrodes. On the other hand, unequivocal local sources of P3 potential were apparently also located outside the regions with a significant hemodynamic response (typically in mesiotemporal regions).

Both methods should be viewed as mutually complementary in investigations of the spatial distribution of cortical and subcortical activation during oddball task.

The study was supported by MSMT CR Research Program no. 112801