Abstract

Knolle, F., Schröger, E., Baess, P., & Kotz, S. A. (2012). The Cerebellum Generates Motor-to-Auditory Predictions: ERP Lesion Evidence. Journal of Cognitive Neuroscience, 24(3), 698-706.

The Cerebellum Generates Motor-to-Auditory Predictions: ERP Lesion Evidence

Forward predictions are crucial in motor action (e.g., catching a ball and being tickled) but may also apply to sensory or cognitive processes (e.g., listening to distorted speech or to a foreign accent). According to the "internal forward model," the cerebellum generates predictions about somatosensory consequences of movements. These predictions simulate motor processes and prepare respective cortical areas for anticipated sensory input. Currently, there is very little evidence that a cerebellar forward model also applies to other sensory domains. In the current study, we address this question by examining the role of the cerebellum when auditory stimuli are anticipated as a consequence of a motor act. We applied an N100 suppression paradigm and compared the ERP response with self-initiated and externally produced sounds. We hypothesized that sensory consequences of self-initiated sounds are precisely predicted and should lead to an N100 suppression compared with externally produced sounds. Moreover, if the cerebellum is involved in the generation of a motor-to-auditory forward model, patients with focal cerebellar lesions should not display an N100 suppression effect. Compared with healthy controls, patients showed a largely attenuated N100 suppression effect. The current results suggest that the cerebellum forms not only motor-to-somatosensory predictions but also motor-to-auditory predictions. This extends the cerebellar forward model to other sensory domains such as audition.



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Cognitive and Biological Psychology

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