Chemical biology and organic chemistry
Modulation of protein-protein interactions with small organic molecules
Protein-protein interactions form the basis of most biological processes, but represent very challenging targets for small organic molecules. The overall aim of our research is to devise innovative methods for the efficient design, development, and identification of small organic modulators of protein-protein interactions. Using an interdisciplinary combination of chemical and biological methods, our work has demonstrated that the inhibition of protein-protein interactions actually represents a powerful approach towards expanding the druggable proteome, and towards the selective inhibition of certain protein kinases. We have been able to identify numerous natural products and natural product-derived inhibitors of protein-protein interactions, and have demonstrated that the inhibition of protein–protein interactions is potentially a hitherto unidentified mode of action of existing therapeutic compounds in human use.
Prof. Dr. Thorsten Berg
University of Leipzig
Institute of Organic Chemistry
Tel.: +49 341 9736-527
Fax: +49 341 9736-599