Pre-conference workshop: Methodological aspects of MMN research
Tuesday, Sep 8, 2015
Recording mismatch negativity and related potentials in neurological patients
Department of Psychology and Edmond and Lily Safra Center for brain sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
The ability to detect and orient to violations of regularity in the sensory environment requires multiple capacities including (non-comprehensive list) sensitivity and adequate resolution within the dimension of variance, sensory memory, predictive coding, attention orienting, and inhibition mechanisms. Thus, recording deviance-related potentials like the MMN, P3a, RON provides a probe into the integrity of these mechanisms in patients who suffer from neurological ailments. Indeed, the MMN and P3a were used to test patients with various neurological conditions, including stroke, coma, and degenerative diseases. In my talk I will discuss how studies can be designed to address well-formed hypotheses about specific conditions, what are the special challenges in recording patients, and what type of conclusions can or cannot be drawn from such studies.